BIOINFORMATICS

Showing posts with label Proteomics. Show all posts

Escape analysis and lock coarsening in JAVA 6.0

The popularity of the Java programming language has made escape analysis a target of interest. Java's combination of heap-only object allocation, built-in threading, and the Sun HotSpot dynamic compiler creates a candidate platform for escape analysis related optimizations. Escape analysis is implemented in Java Standard Edition 6.

Example (Java)

class A {
  final int finalValue;
 
  public A( B b ) {
    super();
    b.doSomething( this ); // this escapes!
    finalValue = 23;
  }
 
  int getTheValue() {
    return finalValue;
  }
}
 
class B {
  void doSomething( A a ) {
    System.out.println( a.getTheValue() );
  }
}

In this example, the constructor for class A passes the new instance of A to B.doSomething. As a result, the instance of A—and all of its fields—escapes the scope of the constructor.

Java is able to manage multithreading at the language level. Multithreading is a technique that allows programs to operate faster on computer system that have multiple CPUs. Also, a multithreaded application has the ability to remain responsive to input, even when it is performing long running tasks.

However, programs that use multithreading need to take extra care of objects shared between threads, locking access to shared methods or blocks when they are used by one of the threads. Locking a block or an object is a time-consuming operation due to the nature of the underlying operating system-level operation involved .

As the Java library does not know which methods will be used by more than one thread, the standard library always locks blocks when necessary in a multithreaded environment.

Prior to Java 6, the virtual machine always locked objects and blocks when asked to by the program even if there was no risk of an object being modified by two different threads at the same time. For example, in this case, a local Vector was locked before each of the add operations to ensure that it would not be modified by other threads (Vector is synchronized), but because it is strictly local to the method this is not necessary:

public String getNames() {
     Vector v = new Vector();
     v.add("Me");
     v.add("You");
     v.add("Her");
     return v.toString();
}

Starting with Java 6, code blocks and objects are locked only when necessary , so in the above case, the virtual machine would not lock the Vector object at all

UC San Diego Undergraduates Forge New Area of Bioinformatics

BioXseed India Launches Biotech Finishing School

Certified Advanced Program in Genomics and Proteomics

The program aims at providing to students a best in class finishing school that would help them enhance employability and offer a pedestal to reach out to the industry.

Aristogene Biosciences is known in the industry for most authentic and practical training in the field of Biosciences. It has a well equipped 8000 sq.ft lab with the required infrastructure to support Research & Training activities. Aristogene also has an
independent R & D and process development wing, which is involved in the development of many products.

BioXseed is the Life Sciences wing of 64 Squares Consulting, a leading HR Services company with various top notch clients.

Course Content:

Tools in Genetic Engineering & Microbiology- Pure culture techniques, Working with phages, Cloning fundamentals, PCR
Cloning & Expression of Gene and Bioinformatics -Know how of complete cloning process, Important Bioinformatics tools, Knowledge ofvector host systems, DNA manipulation techniques, Expression and analysis of clones

Immunotechnology- Immunoprecipitaion and Agglutination techniques, Use of immunotechniques in diagnosis, ELISA, Blotting techniques
Protein Purification Techniques-Various chromatography techniques, Protein analysis by SDS-PAGE and western blotting, Enzymology.
Polymerase chain reaction & Hybridization techniques-A strong foundation for PCR based experiments - Gene amplification, RAPD analysis and related experiments, PCR - RFLP and related experiments, Southern hybridization.

Tools and techniques for success at workplace - Acquire the skills required for your all-round effectiveness like

o Understanding corporate environment,
o Getting your strengths noticed,
o Creative problem solving skills
o Business Etiquettes and personal grooming and the like.

Faculty for the Program:

Sudha with 19 years of experience specializing in Protein and nucleic acid purification, process improvement, product development, Phages, Plasmids, Restriction enzymes, and recombinant technology, and cancer cell biology.

Vasudha with 20 years of experience specializing in Cloning and Expression of restriction and modifying enzymes
Dr CR Subhashini with 15 years of experience specializing in Molecular Diagnostics & Immunology.
Ruskinn D with 11 years of experience specializing in Microbiology, Manufacturing & Instrumentation.
Shuchi Shukla with 9 years Corporate HR experience in high-end niche technology sectors.
Visiting Faculty from Industry.

Unique Features of this Advanced Program in Genomics and Proteomics:

Unique opportunity to enhance employability.
Advanced course that matches industry requirements with contents generally not covered in regular courses at college.
Student-Industry-Academia Interface. Industry Leaders will be invited to share real life experience with students.
A strong emphasis on hands-on laboratory training.
Training under the guidance of scientists with more than two decades of industry experience.
Proven track record in Industry Integration Program.
Limited enrollments with an individualized industrial learning environment.
Counseling services to students.
Curriculum and experienced speakers carefully selected to emphasize practical approaches.
Special Placement assistance program including Resume writing, Interview tips, Mock Interviews etc

Key Dates for the Program:

Travel & accommodation assistance can be provided for outstation students.

For more information Please fill out this Contact form or email at info@bioxseedindia.com ; shuchi@64sqs.com ; lifesc@64sqs.com Or
Call at +91-9845215711 (Bangalore)/ +91-9953100729 (Delhi).

Download Application Form

Download Information Brochure

Apply Online

Evolution of the protein kinase family

Evolution of the protein kinase family - Video Lecture A protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation). Phosphorylation usually results in a functional change of the target protein (substrate) by changing enzyme activity, cellular location, or association with other proteins.